AmphotericinBisapolyeneantifungalcompoundthatincreaseslevelsofROSandformsporesorchannelsinmembranesbybindingmembranesterols.AmphotericinBinducesiNOS,activatesastrocytes,andincreasesexpressionofIL-1β,TNF-α,BDNF,andGDNF,displayingpotentialneuroprotectiveactivityandtherapeuticeffectsinmodelsofpriondiseases.
| CasNo. | 1397-89-3 |
|---|---|
| Purity | ≥87% |
| Formula | C47H73NO17 |
| FormulaWt. | 924.08 |
| IUPACName | (1S,3R,4E,6E,8E,10E,12E,14E,16E,18S,19R,20R,21S,25R,27R,30R,31R,33S,35R,37S,38R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxABIcyclo[33.3.1]nonatriaconta-4,6,8,10,12,14,16-heptaene-38-carboxylicacid |
| Synonym | Ampho-Moronal;Fungilin;Fungizone |
| MeltingPoint | >170°C(dec) |
| Solubility | SolubleinDMSO(30-40mg/mL),DMF(2-4mg/mL)orwater(pH2or11). |
| Appearance | Orange-yellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5130MSDSPDF |
|---|---|
| InfoSheet | A5130InfoSheetPDF |
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NakagawaY,UmegawaY,TakanoT,etal.EffectofsterolsidechainonionchannelformationbyamphotericinBinlipidbilayers.Biochemistry.2014May20;53(19):3088-94.PMID:24762132.
Motoyoshi-YamashiroA,TamuraM,MoriyamaM,etal.ActivationofculturedastrocytesbyamphotericinB:stimulationofNOandcytokinesproductionandchangesinneurotrophicfactorsproduction.NeuRochemInt.2013Aug;63(2):93-100.PMID:23727061.
