AnabasineisanalkaloidoriginallyfoundinspeciesofNicotiana;itisastructuralisomerofnicotine.Anabasineinhibitsaromataseandnicotinicacetylcholinereceptors(nAChRs)andmayproduceadepolarizingneuromuscularjunction(NMJ)block.AnabasinecanalsobeusedasaclinicalbioMarkerfortobaccosmokeexposure.Additionally,anabasineisteratogenicandmaybeusedasaninsecticide.
| CasNo. | 15251-47-5 |
|---|---|
| Purity | ≥98% |
| Formula | C10H14N2•HCl |
| FormulaWt. | 198.73 |
| ChemicalName | 3-(2-Piperidinyl)pyridinehydrochloride |
| IUPACName | 3-piperidin-2-ylpyridine;hydrochloride |
| Solubility | Solubleinwateroralcohol. |
| Appearance | Whitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A5202InfoSheetPDF |
|---|
GreenBT,LeeST,WelchKD,etal.Plantalkaloidsthatcausedevelopmentaldefectsthroughthedisruptionofcholinergicneurotransmission.BirthDefectsResCEmbryoToday.2013Dec;99(4):235-46.PMID:24339035.
ShimomuraM,YokotaM,IharaM,etal.Roleintheselectivityofneonicotinoidsofinsect-specificbasicresiduesinloopDofthenicotinicacetylcholinereceptoragoNISTbindingsite.MolPharmacol.2006Oct;70(4):1255-63.PMID:16868180.
JacobP3rd,YuL,ShulginAT,BenowitzNL.Minortobaccoalkaloidsasbiomarkersfortobaccouse:comparisonofusersofcigarettes,smokelesstobacco,cigars,andpipes.AmJPublicHealth.1999May;89(5):731-6.PMID:10224986.
BarbieriRL,GochbergJ,RyanKJ.Nicotine,cotinine,andanabasineinhibitaromataseinhumantrophoblastinvitro.JClinInvest.1986Jun;77(6):1727-33.PMID:3711333.
