ApramycinisanaminoglycosideantibioticoriginallyproducedbyStreptomyces.Apramycinisclinicallyusedinveterinarymedicine.Thiscompoundbinds16SrRNAofthebacterial30Sribosomalsubunit,causingconformationalchangesinCAandGAbasepairsandinhibitingRNAtranslocation.
| CasNo. | 65710-07-8 |
|---|---|
| Purity | ≥98% |
| Formula | C21H41N5O11•H2O4S |
| FormulaWt. | 637.66 |
| ChemicalName | O-4-Amino-4-deoxy-α-D-glucopyranosyl-(1->8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1->4)-2-deoxy-D-streptamine |
| IUPACName | (2R,3R,4S,5S,6S)-2-[[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-5-amino-6-(hydroxymethyl)oxane-3,4-diol;sulfuricacid |
| Synonym | NEBramycinfactor2;EL-857;Apralan |
| Appearance | Yellow/yellowishpowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A6264MSDSPDF |
|---|---|
| InfoSheet | A6264InfoSheetPDF |
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ChoiMJ,LimSK,NamHM,etal.ApramycinandgentamicinresistancesinindicatorandclinicalEscherichiacoliisolatesfromfarmanimalsinKorea.FoodbornePathogDis.2011Jan;8(1):119-23.PMID:21214385.
