Description
ArtesunateisasesquiterpenelactonederivedfromArtemisia.Artesunateexhibitsanticancerchemotherapeutic,antiviral,anti-angiogenic,andanti-parasiticactivities.Artemisininssuchasartesunatearebestknownfortheirantimalarialactivity.ArtesunateinducesG0/G1phasecellcyclearrest,increaseslevelsofBaxandcaspase3,anddecreaseslevelsofBcl-2,inhibitingtumorgrowthinanimalmodelsofbreastcancer.Inmodelsofcervicalcancer,artesunateinhibitsproductionofprostaglandinE2(PGE2)anddecreasesthenumberofTregcells,alsoinhibitingtumorgrowth.ArtesunateinducescellcyclearrestandinhibitsreplicationofPolyomavirusaswell.Additionally,thiscompoundinhibitsneovascularizationandinflammationincorneas,increasingtheBax/Bcl-2ratioandROSlevels,decreasingthemitochondrialmembranepotential,andactivatingp38MAPK.
References
ZhangLX,LiuZN,YeJ,etal.Artesunateexertsananti-immunosuppressiveeffectoncervicalcancerbyinhibitingPGE2productionandFoxp3expression.CellBiolInt.2014May;38(5):639-46.PMID:24446394.
DongHY,WangZF.AntitumoreffectsofartesunateonhumanbreastcarcinomaMCF-7cellsandIGF-IRexpressioninnudemicexenografts.ChinJCancerRes.2014Apr;26(2):200-7.PMID:24826061.
SharmaBN,MarschallM,HenriksenS,etal.AntiviraleffectsofartesunateonpolyomavirusBKreplicationinprimaryhumankidneycells.AntimicrobAgentsChemother.2014Jan;58(1):279-89.PMID:24145549.
ChengR,LiC,LiC,etal.TheartemisininderivativeartesunateinhibitscornealneovascularizationbyinducingROS-dependentapoptosisinvascularendothelialcells.InvestOphthalmolVisSci.2013May15;54(5):3400-9.PMID:23611999.
GomesTC,deAndradeJúniorHF,LescanoSA,etal.Invitroactionofantiparasiticdrugs,especiallyartesunate,againstToxoplasmagondii.RevSocBrasMedTrop.2012Jul-Aug;45(4):485-90.PMID:22930046.
HaynesRK,ChanWC,WongHN,etal.Facileoxidationofleucomethyleneblueanddihydroflavinsbyartemisinins:relationshipwithflavoenzymefunctionandantimalarialmechanismofaction.ChemMedChem.2010Aug2;5(8):1282-99.PMID:20629071.
