LKT/AZACITIDINE/A9602/1 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/AZACITIDINE/A9602/1 g

LKT/AZACITIDINE/A9602/1 g

商品编号： A9602-1g

品牌： lktlabs

市场价： ¥6740.00

美元价： 4044.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDA9602

CasNo.320-67-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

AzacytidineisacytidineanalogthatisincorporatedintoDNA,inhibitingDNAmethyltransferase(DNMT)activityandpreventingDNArepair.Thisdemethylatingagentisclinicallyusedtotreatmyelodysplasticsyndromesandpotentiatestheeffectsofotherchemotherapeutics,suchascisplatin.Azacytidineexhibitsanticancerchemotherapeutic,immunomodulatory,andantiviralactivities.Invitro,azacytidineincreaseslevelsofBaxandBcl-2inastrocytomacells,andinducesdifferentiationofmesenchymalstemcellsintocardiomyocytes.Invivo,azacytidineincreasesglialdifferentiationanddecreasescellproliferation,inhibitingtumorgrowthofgliomaxenografts.Additionally,azacytidinedecreasescellgrowthandinhibitstumorxenograftsofmyelodysplasticcells.Inleukoblasts,thiscompoundupregulatestheexpressionoftumorantigens,andinvivo,itincreasesthenumberofTregandCD8+Tcells.AzacytidinealsoinhibitsreplicationofHIVincellularmodelswithoutdisplayingcytotoxicity.

ProductInfo

CasNo.	320-67-2
Purity	≥98%
Formula	C₈H₁₂N₄O₅
FormulaWt.	244.20
ChemicalName	4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
IUPACName	4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
Synonym	4-Amino-1-(≤-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one,Ladakamycin,5-azacytidine.
MeltingPoint	226-232°C
Solubility	Solubleinwater,butunstable.
Appearance	Whiteoralmostwhitecrystallinepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	A9602InfoSheetPDF
Brochures	EpigeneticModifiersBooklet

References

BorodovskyA,SalmasiV,TurcanS,etal.5-azacytidinereducesmethylation,promotesdifferentiationandinducestumorregressioninapatient-derivedIDH1mutantgliomaxenograft.Oncotarget.2013Oct;4(10):1737-47.PMID:24077805.

Solís-ParedesM,Eguía-AguilarP,Chico-PoncedeLeónF,etal.Epigeneticmodificationsincelllinesofhumanastrocytomadifferentiallyregulateexpressionofapoptoticgenes.ChildsNervSyst.2013Aug13.Epubaheadofprint.PMID:23943192.

TsujiokaT,YokoiA,UesugiM,etal.EffectsofDNAmethyltransferaseinhibitors(DNMTIs)onMDS-derivedcelllines.ExpHematol.2013Feb;41(2):189-97.PMID:23085465.

KimuraS,KuramotoK,HomanJ,etal.AntiproliferativeandantitumoreffectsofazacitidineagainstthehumanmyelodysplasticsyndromecelllineSKM-1.AnticancerRes.2012Mar;32(3):795-8.PMID:22399596.

GoodyearOC,DennisM,JilaniNY,etal.AzacitidineaugmentsexpansionofregulatoryTcellsafterallogeneicstemcelltransplantationinpatientswithacutemyeloidleukemia(AML).Blood.2012Apr5;119(14):3361-9.PMID:22234690.

YeNS,ChenJ,LuoGA,etal.Proteomicprofilingofratbonemarrowmesenchymalstemcellsinducedby5-azacytidine.StemCellsDev.2006Oct;15(5):665-76.PMID:17105402.

BouchardJ,WalkerMC,LeclercJM,etal.5-azacytidineand5-azadeoxycytidineinhibithumanimmunodeficiencyvirustype1replicationinvitro.AntimicrobAgentsChemother.1990Feb;34(2):206-9.PMID:1691617.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂