Description
AZD-1480isaninhibitorofJAK1/2thatexhibitsantiviral,immunosuppressive,anti-metastatic,andanticancerchemotherapeuticactivities.Invitro,AZD-1480inhibitsreplicationofhepatitisAvirus.Inanimalmodelsofexperimentalautoimmuneencephalitis(EAE),AZD-1480decreasesdiseaseseveritybysuppressingexpressionofinflammatorycytokinesandminimizingantigenpresentationandTcellexpansion.Inanimalmodelsofvariouscancers,thiscompoundinhibitstumorgrowth.AZD-1480iscurrentlyinclinicaltrialsasapotentialcancertreatment.Incellularandanimalmodelsofprostatecancer,thiscompoundinhibitsmetastasis.
References
JiangX,KandaT,NakamotoS,etal.TheJAK2inhibitorAZD1480inhibitshepatitisAvirusreplicationinHuh7cells.BiochemBiophysResCommun.2015Feb19.[Epubaheadofprint].PMID:25704089.
GritsinaG,XiaoF,O"BrienSW,etal.TargetedblockadeofJAK/STAT3signalinginhibitsovariancarcinomagrowth.MolCancerTher.2015Feb2.[Epubaheadofprint].PMID:25646015.
SuryaniS,BrackenLS,HarveyRC,etal.EvaluationoftheInVitroandInVivoEfficacyoftheJAKInhibitorAZD1480againstJAK-MutatedAcuteLymphoblasticLeukemia.MolCancerTher.2015Feb;14(2):364-74.PMID:25504635.
HoughtonPJ,KurmashevaRT,LyalinD,etal.Initialsolidtumortesting(stage1)ofAZD1480,aninhibitorofJanuskinases1and2bythepediatricpreclinicaltestingprogram.PediatrBloodCancer.2014Nov;61(11):1972-9.PMID:25131802.
GuL,TalatiP,VogiatziP,etal.PharmacologicsuppressionofJAK1/2byJAK1/2inhibitorAZD1480potentlyinhibitsIL-6-inducedexperimentalprostatecancermetastasesformation.MolCancerTher.2014May;13(5):1246-58.PMID:24577942.
LiuY,HoldbrooksAT,DeSarnoP,etal.TherapeuticefficacyofsuppressingtheJak/STATpathwayinmultiplemodelsofexperimentalautoimmuneencephalomyelitis.JImmunol.2014Jan1;192(1):59-72.PMID:24323580.
