Azithromycinisanazalidemacrolideantibioticderivedfromerythromycin.Azithromycinbindsthebacterial50Sribosomalsubunit,inhibitingproteintranslation.Azithromycindisplaysantibacterial,anti-fibrotic,andanti-inflammatoryactivities.Inepithelialcells,azithromycininhibitstheepithelial-to-mesenchymaltransition(EMT)byinhibitingexpressionofSmad3.Additionally,azithromycininhibitsproductionofarachidonicacid,eicosanoids,IL-6,andIL-12inLPS-stimulatedmacrophages.
| CasNo. | 117772-70-0 |
|---|---|
| Purity | ≥98% |
| Formula | C38H72N2O12•2H2O |
| FormulaWt. | 785.02 |
| ChemicalName | [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,-14R*)]-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamio)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one |
| IUPACName | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one |
| Synonym | Azitrocin;Ribotrex;Sumamed;Zithromax;Zitromax |
| MeltingPoint | 113-115°C |
| Solubility | Slightlysolubleinwater.DMSO:100mg/mL,Ethanol:100mg/mL |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A9834MSDSPDF |
|---|---|
| InfoSheet | A9834InfoSheetPDF |
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