Bafilomycin A1 is a macrolide antibiotic initially produced by Streptomyces that exhibits anti-parasitic, antimalarial, and anticancer chemotherapeutic activities. Bafilomycin A1 inhibits the vacuolar H+ ATPase and suppresses autophagy. Bafilomycin kills Plasmodium parasites in cellular models, and separately, induces cell death and suppresses tumor growth in animal models of breast cancer.
| Cas No. | 88899-55-2 |
|---|---|
| Purity | ≥90% |
| Formula | C35H58O9 |
| Formula Wt. | 622.83 |
| IUPAC Name | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one |
| Solubility | Soluble in DMSO, ethanol and methanol. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | B0025 MSDS PDF |
|---|---|
| Info Sheet | B0025 Info Sheet PDF |
Graham RM, Thompson JW, Webster KA. Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis. Oncotarget. 2014 Mar 15;5(5):1162-73. PMID: 24811485.
Xu MY, Lee SY, Kang SS, et al. Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy. J Nat Prod. 2014 Feb 28;77(2):370-6. PMID: 24547878.
van Schalkwyk DA, Chan XW, Misiano P, et al. Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. Biochem Pharmacol. 2010 May 1;79(9):1291-9. PMID: 20067768.
