Bafilomycin B1 is a macrolide antibiotic that also exhibits antifungal activity. Bafilomycin B1 inhibits the vacuolar H+ ATPase. Additionally, bafilomycin B1 inhibits Foxo1 and increases β cell apoptosis, accelerating the onset of diabetes.
| Cas No. | 88899-56-3 |
|---|---|
| Purity | ≥97% |
| Formula | C44H65NO13 |
| Formula Wt. | 815.99 |
| Chemical Name | Hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)carbonyl)-2-methoxy-24-methyl- |
| IUPAC Name | [(2R,4R,5S,6R)-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,6Z,9S,10S,11R,12Z,14E)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl](E)-4-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-4-oxobut-2-enoate |
| Synonym | Setamycin |
| Melting Point | 89-96°C (dec) |
| Solubility | Soluble in methanol. |
| Appearance | Yellow Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | B0026 MSDS PDF |
|---|---|
| Info Sheet | B0026 Info Sheet PDF |
Schachtschabel D, Arentshorst M, Lagendijk EL, et al. Vacuolar H(+)-ATPase plays a key role in cell wall biosynthesis of Aspergillus niger. Fungal Genet Biol. 2012 Apr;49(4):284-93. PMID: 22222772.
Hettiarachchi KD, Zimmet PZ, Danial NN, et al. Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas. Exp Toxicol Pathol. 2008 Aug;60(4-5):295-306. PMID: 18486461.
