Betulinisapentacyclictriterpenefoundinbirchbark.Thiscompoundcaninduceapoptosisandinhibitangiogenesis,lendingitawidevarietyoffunctions,includinganticancer,antiviral,anti-inflammatory,anti-fibrotic,antioxidative,andantibacterialroles.Betulinishepatoprotectiveaswell,asitsuppressessymptomsofethanol-inducedfattyliverbyinhibitingacidophilicnecrosis;italsopreventsliverfibrosisbyinhibitingproductionandmigrationofROS.
| CasNo. | 473-98-3 |
|---|---|
| Purity | ≥98% |
| Formula | C30H50O2 |
| FormulaWt. | 442.72 |
| ChemicalName | Lup-20(29)-ene-3β,28-diol |
| IUPACName | (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol |
| MeltingPoint | 256–257°C |
| Appearance | Whitepowder |
| ShipTemp | Ambient |
|---|
| InfoSheet | B1977InfoSheetPDF |
|---|
WanY,JiangS,LianLH,etal.Betulinicacidandbetulinameliorateacuteethanol-inducedfattyliverviaTLR4andSTAT3invivoandinvitro.IntImmunopharmacol.2013Jun28;17(2):184-190.[Epubaheadofprint]PMID:23816536.
JonnalagaddaSC,CorselloMA,SleetCE.Betulin-BetulinicAcidNaturalProductBasedAnalogsasAnti-CancerAgents.AnticancerAgentsMedChem.2013Jun11.[Epubaheadofprint]PubMedPMID:23848199.
Szuster-CiesielskaA,PlewkaK,Kandefer-SzerszeńM.Betulin,betulinicacidandbuteinareinhibitorsofacetaldehyde-inducedactivationofliverstellatecells.PharmacolRep.2011;63(5):1109-23.PMID:22180353.
