Description
BiochaninAisanisoflavone/flavonoidfoundinplantsintheFabaceaefamily,suchasclover,soy,andalfalfa.BiochaninAexhibitsanticancer,anti-metastatic,estrogenic,neuroprotective,anti-osteoporotic,antiviral,andanti-inflammatoryactivities.BiochaninAmayactivatePPARαandPPARγ.Inpancreaticcancercells,biochaninAinhibitscellularproliferation,migration,andinvasion,andsuppressesactivationofAktandMAPKs.Inothercellularmodels,biochaninAactsasaphytoestrogenandincreasesexpressionofERβ.BiochaninAalsoimprovescognitivedeficitsinanimalmodelsofAlzheimer’sdisease.Instemcells,thiscompoundinhibitsADIpocytedifferentiationandincreasesosteoblastdifferentiation.Additionally,biochaninAinhibitsreplicationofinfluenzavirusandsuppressesproductionofIL-6,IL-8,IL-10,andTNF-αinvitro.
References
WangL,WaltenbergerB,Pferschy-WenzigEM,etal.Naturalproductagonistsofperoxisomeproliferator-activatedreceptorgamma(PPARγ):areview.BiochemPharmacol.2014Jul30.[Epubaheadofprint].PMID:25083916.
BiradarSM,JoshiH,ChhedaTK.Biochanin-AamelioratesbehaviouralandneuRochemicalderangementsincognitive-deficitmiceforthebettermentofAlzheimer"sdisease.HumExpToxicol.2014Apr;33(4):369-82.PMID:23900307.
BhardwajV,TadinadaSM,JainA,etal.BiochaninAreducespancreaticcancersurvivalandprogression.AnticancerDrugs.2014Mar;25(3):296-302.PMID:24201306.
NyncaA,SwigonskaS,PiaseckaJ,etal.BiochaninAaffectssteroidogenesisandestrogenreceptor-βexpressioninporcinegranulosacells.Theriogenology.2013Oct15;80(7):821-8.PMID:23953692.
SuSJ,YehYT,SuSH,etal.BiochaninapromotesosteogenicbutinhibitsAdipogenicdifferentiation:evidencewithprimaryadipose-derivedstemcells.EvidBasedComplementAlternatMed.2013;2013:846039.PMID:23843885.
SithisarnP,MichaelisM,Schubert-ZsilaveczM,etal.Differentialantiviralandanti-inflammatorymechanismsoftheflavonoidsbiochaninAandbaicaleininH5N1influenzaAvirus-infectedcells.AntiviralRes.2013Jan;97(1):41-8.PMID:23098745.
