LKT/BREFELDIN A/B6816/10 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/BREFELDIN A/B6816/10 mg

LKT/BREFELDIN A/B6816/10 mg

商品编号： B6816-10mg

品牌： lktlabs

市场价： ¥2240.00

美元价： 1344.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDB6816

CasNo.20350-15-6

Purity≥97%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

BrefeldinAisalactoneantibioticfoundinfungisuchasEupenicillium;itexhibitsanticancerandantiviralactivities.BrefeldinAinhibitsactivityofguaninenucleotideexchangefactors,preventingassociationwithCOPIandCOPI-mediatedvesicleformationandsuppressingproteintransportfromtheendoplasmicreticulumtotheGolgiapparatus.BrefeldinAisusedinresearchmodelstostudyendoplasmicreticulumstressandproteintransport.Invitro,thiscompoundinhibitspoliovirusreplication.Inprostatecancercells,brefeldinAinhibitscellgrowth,inducesapoptosisandG1phasecellcyclearrest,decreaseslevelsofp53,CDK2,CDK4,andcyclinD1,andcausescelldeath.

ProductInfo

CasNo.	20350-15-6
Purity	≥97%
Formula	C₁₆H₂₄O₄
FormulaWt.	280.36
ChemicalName	1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
IUPACName	(1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxABIcyclo[11.3.0]hexadeca-2,10-dien-9-one
Synonym	Ascotoxin;Cyanein;Decumbin
MeltingPoint	204-205°C
Solubility	Solubleinmethanol.
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	B6816MSDSPDF
InfoSheet	B6816InfoSheetPDF

References

ZhouC,LiC,LiD,etal.BIG1,abrefeldinA-inhibitedguaninenucleotide-exchangeproteinregulatesneuritedevelopmentviaPI3K-AKTandERKsignalingpathways.Neuroscience.2013Dec19;254:361-8.PMID:24090963.

RouhanaJ,PADIllaA,EstaranS,etal.KineticsofinteractionbetweenADP-ribosylationfactor-1(Arf1)andtheSec7domainofArnoguaninenucleotideexchangefactor,modulationbyallostericfactors,andtheuncompetitiveinhibitorbrefeldinA.JBiolChem.2013Feb15;288(7):4659-72.PMID:23255605.

ChapmanJR,TazakiH,MallouhC,etal.BrefeldinA-inducedapoptosisinprostaticcancerDU-145cells:apossIBLep53-independentdeathpathway.BJUInt.1999Apr;83(6):703-8.PMID:10233583.

CuconatiA,MollaA,WimmerE.BrefeldinAinhibitscell-free,denovosynthesisofpoliovirus.JVirol.1998Aug;72(8):6456-64.PMID:9658088.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂