BrivudineisaL-nucleosideanalogofthymidinethatexhibitsantiviral,anticancerchemotherapeutic,andinsecticidalactivities.Brivudineinhibitsherpessimplexvirus(HSV-1)thymidinekinase,preventingDNAchainelongationandinhibitingviralgrowth.Brivudinealsobindsheatshockprotein27(HSP27/HSPB1),improvingtheefficacyofco-admiNISTeredchemotherapeuticsinvivoandinclinicalsettings.Thiscompoundalsoexhibitspropertiesofaninsecticide,slowinglarvalgrowthanddevelopmentofSpodopteraworms.
| CasNo. | 69304-47-8 |
|---|---|
| Purity | ≥98% |
| Formula | C11H13BrN2O5 |
| FormulaWt. | 333.13 |
| ChemicalName | 5-[(E)-2-bromoethenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione |
| IUPACName | 5-[(E)-2-bromoethenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| MeltingPoint | 165°C |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B6935InfoSheetPDF |
|---|
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BalzariniJ,BohmanC,DeClercqE.Differentialmechanismofcytostaticeffectof(E)-5-(2-bromovinyl)-2"-deoxyuridine,9-(1,3-dihydroxy-2-propoxymethyl)guanine,andotherantiherpeticdrugsontumorcellstransfectedbythethymidinekinasegeneofherpessimplexvirustype1ortype2.JBiolChem.1993Mar25;268(9):6332-7.PMID:8384209.
