Butoconazoleisanimidazolederivativethatexhibitsantifungal/antimycoticandanti-parasiticactivities;itlikelyinhibits14-αdemethylase.ButoconazoledisplaysparticularlyeffectiveantimicrobialactivityagainstspeciesofCandida,Saccharomyces,andTrichomonas.
| CasNo. | 64872-77-1 |
|---|---|
| Purity | ≥98% |
| Formula | C19H17Cl3N2S•HNO3 |
| FormulaWt. | 474.79 |
| IUPACName | 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenyl)sulfanylbutyl]imidazole;nitricacid |
| MeltingPoint | 159°C(dec.) |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B8278InfoSheetPDF |
|---|
SeidmanLS,SkokosCK.Anevaluationofbutoconazolenitrate2%sitereleasevaginalcream(Gynazole-1)comparedtofluconazole150mgtablets(Diflucan)inthetimetoreliefofsymptomsinpatientswithvulvovaginalcandidiasis.InfectDisObstetGynecol.2005Dec;13(4):197-206.PMID:16338779.
BouréeP,IssoireC.InvitroevaluationoftheactivityofbutoconazoleagainstTrichomonasvaginalis.PatholBiol(Paris).1992May;40(5):492-4.PMID:1495832.
HernándezMolinaJM,LlosáJ,MartinezBrocalA,etal.Invitroactivityofcloconazole,sulconazole,butoconazole,isoconazole,fenticonazole,andfiveotherantifungalagentsagainstclinicalisolatesofCandidaalbicansandCandidaspp.Mycopathologia.1992Apr;118(1):15-21.PMID:1406898.
