Carveol is a terpene alcohol initially found in spearmint oil that exhibits anti-parasitic, neuromodulatory, and anticancer activities. Carveol is commercially used as a food additive and fragrance. This compound activates transient receptor potential vanilloid 3 (TRPV3) channels in vitro and displays acaricidal characteristics, inhibiting growth of Dermatophagoides. In prostate cancer cells, carveol increases levels of p21 and activation of ERK, suppressing cellular proliferation.
| Cas No. | 99-48-9 |
|---|---|
| Purity | ≥98% |
| Formula | C10H16O |
| Formula Wt. | 152.23 |
| Chemical Name | p-Mentha-6,8-dien-2-ol |
| IUPAC Name | 2-methyl-5-prop-1-en-2-ylcyclohex-2-en-1-ol |
| Solubility | Insoluble in water. Soluble in ethanol, or DMSO. |
| Appearance | Clear Light Yellow Liquid |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | C0368 MSDS PDF |
|---|---|
| Info Sheet | C0368 Info Sheet PDF |
Yang JY, Kim MG, Lee SE, et al. Acaricidal activities against house dust mites of spearmint oil and its constituents. Planta Med. 2014 Feb;80(2-3):165-70. PMID: 24488719.
Bhatia SP, McGinty D, Letizia CS, et al. Fragrance material review on carveol. Food Chem Toxicol. 2008 Nov;46 Suppl 11:S85-7. PMID: 18640224.
Vogt-Eisele AK, Weber K, Sherkheli MA, et al. Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40. PMID: 17420775.
Chen J, Lu M, Jing Y, et al. The synthesis of L-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells. Bioorg Med Chem. 2006 Oct 1;14(19):6539-47. PMID: 16806947.
