Description
Terpinen-4-olisamonoterpeneoriginallyfoundinmanyplantsandisoneoftheprimaryactiveingredientsinteatreeoil.Terpinen-4-olexhibitsanticancerchemotherapeutic,anti-inflammatory,antibacterial,andantifungalactivities.Inleukemiacells,terpinen-4-olinducesreleaseofcytochromecandactivationofcaspase8,resultinginautophagy,apoptosis,andcelldeath.Innon-smallcelllungcancer(NSCLC)cells,terpinen-4-olinducescleavageofpoly(ADP)-ribosepolymerase(PARP),activatescaspases3and9,decreasesmitochondrialmembranepotential,increasestheBax/Bcl-2ratio,andincreaseslevelsofp53,resultinginapoptosisandcelldeath.Additionally,thiscompounddecreasesmyeloperoxidaseactivityandexpressionofMIP-2andothercytokinesinanimalmodelsoforalcandidiasis.Terpinen-4-oldisplaysantimicrobialactivityagainstgrampositiveandgramnegativebacteriasuchasCampylobacteraswellasfungisuchasAspergillusandFusarium.
References
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