Description
Theaflavin-3-gallateisapolyphenoliccompoundfoundinblacktea.Thetheaflavinsareformedduringtheenzymaticoxidationofcatechins,whichhappensduringprocessingofthefreshtealeaves.Theaflavin-3-gallatehasbeenshowntohaveinhibitoryeffectsonovariancancercellsOVCAR-3andA2780/CP70byinducingapoptosisandimpairingtumorangiogenesis.Inaddition,theaflavin-3-gallatewasfoundtogivestrongerreactiveoxygenspeciesscavengingactivitythantheaflavinbyachemiluminescenceassay.ExposureofCAL27andHSC-2carcinomacellstotheaflavin-3-gallatedemostratedcytotoxicandantiproliferativepropertiesofthecompound.