Thiamphenicolisachloramphenicolanalogthatexhibitsantibioticactivity.Thiamphenicolinhibitsthe50Ssubunitofthebacterialribosome,inhibitingproteintranslation.ThiamphenicoldisplaysantibacterialefficacyagainstStreptococcus,Staphylococcus,Escherichia,andHaemophilus.
| CasNo. | 2611-61-2 |
|---|---|
| Purity | ≥98% |
| Formula | C14H18Cl2N2O6S•HCl |
| FormulaWt. | 449.7 |
| ChemicalName | 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-hydroxymethyl-2-[4-methylsulphonyl)phenyl]ethyl]acetamideglycinatehydrochloride |
| IUPACName | [(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-methylsulfonylphenyl)propyl]2-aminoacetate;hydrochloride |
| Synonym | NeomysonGHCl;UrfamicinHCl |
| Solubility | SolubleinwaterandDMF. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T2932InfoSheetPDF |
|---|
RaymondJ,BoutrosN,BergeretM.Roleofthiamphenicolinthetreatmentofcommunity-acquiredlunginfections.MedTrop(Mars).2004;64(1):33-8.PMID:15224555.
MarcheseA,DebbiaEA,TonoliE,etal.InvitroactivityofthiamphenicolagainstmultiresistantStreptococcuspneumoniae,HaemophilusinfluenzaeandStaphylococcusaureusinItaly.JChemother.2002Dec;14(6):554-61.PMID:12583545.
