LKT/THIORIDAZINE HYDROCHLORIDE/T2936/5 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/THIORIDAZINE HYDROCHLORIDE/T2936/5 g

LKT/THIORIDAZINE HYDROCHLORIDE/T2936/5 g

商品编号： T2936-5g

品牌： lktlabs

市场价： ¥1740.00

美元价： 1044.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDT2936

CasNo.130-61-0

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

ThioridazineisapiperADInephenothiazinederivativeclassifiedasa‘typical’antipsychoticforitspotentinhibitionofD2receptors.ThioridazinedisplaysactivityatD1-5receptors,H1/2histaminereceptors,M1-5muscarinicacetylcholinereceptors(mAChRs),α1/2-adrenergicreceptors,and5-HT1/2/5/6/7receptors;thioridazinealsomodulatesactivityofthenorepinephrinetransporter(NET).Inadditiontoitswell-establishedantipsychoticandsedativeactivities,thioridazinealsoexhibitsantibacterial,anti-angiogenic,andanticancerproperties.Invitro,thioridazineenhancesβ-lactamantibacterialcapABIlities;thiscompoundinhibitspeptidoglycansynthesisbyinterferingwiththeformationofpentaglycinebranchesandinducingaminoacidshortages.ThioridazineinhibitsphosphorylationofAkt,PDK-1,mTOR,andp70S6K,inhibitingmigration,invasion,andcapillary-liketubeformationofcells.Incervicalandendometrialcancercells,thioridazinedownregulatesexpressionofcyclinsD1andAaswellascyclin-dependentkinase4(CDK4)andupregulatesexpressionofp21andp27,inducingapoptosis.Invivo,thiscompounddecreasescolony-formingunitsofMycobacteriumtuberculosis,inducingexpressionofthesigma6regulonandRv3160c-Rv3161coperon.Thioridazine,likeotherantipsychotics,alsoinhibitshERGK+channels,potentiallyinducingQTprolongationandactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).

ProductInfo

CasNo.	130-61-0
Purity	≥98%
Formula	C₂₁H₂₆N₂S₂•HCl
FormulaWt.	407.04
IUPACName	10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride
MeltingPoint	158-160°C
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	T2936MSDSPDF
InfoSheet	T2936InfoSheetPDF

References

ThorsingM,KlitgaardJK,AtilanoML,etal.Thioridazineinducesmajorchangesinglobalgeneexpressionandcellwallcompositioninmethicillin-resistantStaphylococcusaureusUSA300.PLoSOne.2013May17;8(5):e64518.PMID:23691239.

ByunHJ,LeeJH,KimBR,etal.Anti-angiogeniceffectsofthioridazineinvolvingtheFAK-mTORpathway.MicrovascRes.2012Nov;84(3):227-34.PMID:23022044.

KangS,DongSM,KimBR,etal.ThioridazineinducesapoptosisbytargetingthePI3K/Akt/mTORpathwayincervicalandendometrialcancercells.Apoptosis.2012Sep;17(9):989-97.PMID:22460505.

RothBL,DriscolJ.PDSPKiDatabase.PsychoactiveDrugScreeningProgram(PDSP).UniversityofNorthCarolinaatChapelHillandtheUnitedStatesNationalInstituteofMentalHealth.2011Jan.

vanSoolingenD,Hernandez-PandoR,OrozcoH,etal.Theantipsychoticthioridazineshowspromisingtherapeuticactivityinamousemodelofmultidrug-resistanttuberculosis.PLoSOne.2010Sep9;5(9).pii:e12640.PMID:20844587.

DuttaNK,MehraS,KaushalD.AMycobacteriumtuberculosissigmafactornetworkrespondstocell-envelopedamagebythepromisinganti-mycobacterialthioridazine.PLoSOne.2010Apr8;5(4):e10069.PMID:20386700.

CrumbWJJr,EkinsS,SarazanRD,etal.EffectsofantipsychoticdrugsonI(to),I(Na),I(sus),I(K1),andhERG:QTprolongation,structureactivityrelationship,andnetworkanalysis.PharmRes.2006Jun;23(6):1133-43.PMID:16715368.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂