Description

Tigecycline is a glycylcycline antibiotic that displays antibacterial activity against gram positive and gram negative bacteria and also exhibits some neuroprotective and anti-inflammatory benefit as well. The antibacterial activity of tigecycline is due to its binding in the A site of the 30S ribosome and resulting inhibition of prokaryotic protein synthesis. In neuronal cells administered LPS, tigecycline prevents release of NF-κB, TNF-α, IL-1β, cytochrome C, decreases levels of NO and Bad, increases expression of Bcl-2, and decreases activity of caspase-3.