Tobramycinisanaminoglycosideantibioticthatexhibitsantibacterialandanti-inflammatoryactivities.Tobramycinpreventsformationofthe70Sbacterialribosomalcomplex,inhibitingproteintranslation;itishighlyeffectiveinthetreatmentofPseudomonasinfections.Invitro,tobramycininhibitsTcellandneutrophilmigration.Inseparatecellularmodels,thiscompoundalsodecreasesactivationofNF-κB,expressionofMUC5AC,andphosphorylationofERKandp38MAPK.
| CasNo. | 32986-56-4 |
|---|---|
| Purity | ≥98% |
| Formula | C18H37N5O9 |
| FormulaWt. | 467.51 |
| ChemicalName | O-3-Amino-3-deoxy-α-d-glucopyranosyl-(1->6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1->4)]-2-deoxy-D-streptamine |
| IUPACName | (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol |
| Synonym | NEBramycinfactor6;NF6;Tobracin;Tobralex;Tobramaxin;Tobrex |
| MeltingPoint | 178°C |
| Solubility | Solubleinwater.Slightlysolubleinethanol.Practicallyinsolubleinetherorchloroform. |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T5604InfoSheetPDF |
|---|
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NakamuraS,YanagiharaK,ArakiN,etal.High-dosetobramycininhibitslipopolysaccharide-inducedMUC5ACproductioninhumanlungepithelialcells.EurJPharmacol.2011Mar21.[Epubaheadofprint].PMID:21414310.
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