Description
Trifluoperazineisaphenothiazineantipsychoticthatisclinicallyusedtotreatschizophreniaandanxiety.Trifluoperazinealsoexhibitsanxiolytic,anti-parasitic,anticancer,andanestheticactivities.Thiscompoundinhibitsα1-adrenergicreceptors,calmodulin,andD1/2receptors.InPlasmodium,trifluoperazineinhibitsCa2+-dependentproteinkinase4(CDPK4).Inlungadenocarcinomacells,trifluoperazinedownregulatesexpressionofF-actinandBcl-2,upregulatesexpressionofBaxandphosphorylationofERKandJNK,inducesapoptosis,andinhibitscellularproliferation.Additionally,thiscompoundinhibitsNav1.4/SCNA4andNav1.7/SCN9ANa+channels,causingsensoryandmotorblockadeinvivo.
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