Description
Tubeimoside I is a triterpene saponin originally found in Bolbostemma that exhibits anti-inflammatory, antiviral, anticancer chemotherapeutic, and chemopreventive activities. Tubeimoside I inhibits LPS-stimulated production of TNF-α, IL-1β, and IL-6, preventing the development of pulmonary edema and infiltration of inflammatory cells in vivo. Tubeimoside I also induces G2/M phase cell cycle arrest and mitochondria-dependent apoptosis in esophageal squamous cell carcinoma cells, inhibiting cell proliferation; in other, similar cellular and animal models, this compound inhibits cell and tumor growth. Tubeimoside I binds tubulin at the colchicine site, inhibiting microtubule polymerization. Additionally, this compound inhibits production of HIV core protein p24 and infectivity of HIV-1 in vitro.
References
Wu Q, Sun G, Yuan X, et al. Tubeimoside-1 attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models. Immunopharmacol Immunotoxicol. 2013 Aug;35(4):514-23. PMID: 23844578.
Xu Y, Wang G, Chen Q, et al. Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death. Chin J Cancer Res. 2013 Jun;25(3):312-21. PMID: 23825908.
Ma R, Song G, You W, et al. Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin. Cancer Chemother Pharmacol. 2008 Sep;62(4):559-68. PMID: 18030471.
Yu L, Ma R, Wang Y, et al. Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum. Planta Med. 1994 Jun;60(3):204-8. PMID: 8073083.
Yu LJ, Ma RD, Jiang SB. Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):103-6. PMID: 8010099.
Yu LJ, Ma RD, Wang YQ, et al. Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet. Int J Cancer. 1992 Feb 20;50(4):635-8. PMID: 1537629.
