TylosinisamacrolideantibioticoriginallyproducedbyStreptomyces.Likeothermacrolides,tylosinbindsthe50Ssubunitofthebacterialribosome,suppressingmitochondrialproteintranslation;itinhibitspeptidyltransferase,preventingtranslocation.TylosindisplaysantibacterialefficacyagainstmostgrampositiveandsomegramnegativebacteriasuchasCampylobacter.
| CasNo. | 1405-53-4 |
|---|---|
| Purity | ≥90% |
| Formula | C46H77NO17•H3PO4 |
| FormulaWt. | 1014.11 |
| IUPACName | 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde;phosphoricacid |
| Synonym | FarmazinTB;Tylosinphophatesalt |
| Solubility | Solubleinwater,alcoholorchloroform. |
| Appearance | Whitetoalmostwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | T9946MSDSPDF |
|---|---|
| InfoSheet | T9946InfoSheetPDF |
LiuM,DouthwaiteS.Resistancetothemacrolideantibiotictylosinisconferredbysinglemethylationsat23SrRNAnucleotidesG748andA2058actinginsynergy.ProcNatlAcadSciUSA.2002Nov12;99(23):14658-63.PMID:12417742.
ZalacainM,CundliffeE.Methylationof23SrRNAcausedbytlrA(ermSF),atylosinresistancedeterminantfromStreptomycesfrADIae.JBacteriol.1989Aug;171(8):4254-60.PMID:2753855.
