TylosinisamacrolideantibioticoriginallyproducedbyStreptomyces.Likeothermacrolides,tylosinbindsthe50Ssubunitofthebacterialribosome,suppressingmitochondrialproteintranslation;itinhibitspeptidyltransferase,preventingtranslocation.TylosindisplaysantibacterialefficacyagainstmostgrampositiveandsomegramnegativebacteriasuchasCampylobacter.
| CasNo. | 1405-54-5 |
|---|---|
| Purity | ≥90% |
| Formula | C46H77NO17•C4H6O6 |
| FormulaWt. | 1066.19 |
| ChemicalName | (R-(R*,R*))-2,3-dihydroxybutanedioateTylosin(salt) |
| IUPACName | (2R,3R)-2,3-dihydroxybutanedioicacid;2-[(4R,5S,7R,9R,11E,13E,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde |
| Synonym | Pharmasin |
| Solubility | Solubleinwater. |
| Appearance | Whitetobuffpowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | T9945MSDSPDF |
|---|---|
| InfoSheet | T9945InfoSheetPDF |
LiuM,DouthwaiteS.Resistancetothemacrolideantibiotictylosinisconferredbysinglemethylationsat23SrRNAnucleotidesG748andA2058actinginsynergy.ProcNatlAcadSciUSA.2002Nov12;99(23):14658-63.PMID:12417742.
ZalacainM,CundliffeE.Methylationof23SrRNAcausedbytlrA(ermSF),atylosinresistancedeterminantfromStreptomycesfrADIae.JBacteriol.1989Aug;171(8):4254-60.PMID:2753855.
