ValinomycinisapeptideantibioticoriginallyproducedbyStreptomyces.ValinomycindisplaysantibacterialefficacybyinhibitinggrowthofStreptomycesandClostridium.ValinomycinisaneutralionophorethattransportsK+ionsthroughcellularmembranes,alteringtheelectRochemicalgrADIent.Invitro,valinomycininducesmitochondrialdamage,oxidativestress,andcaspaseexpression.
| CasNo. | 2001-95-8 |
|---|---|
| Purity | ≥98% |
| Formula | C54H90N6O18 |
| FormulaWt. | 1111.32 |
| IUPACName | 6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone |
| Synonym | Valinomicin |
| MeltingPoint | 190°C |
| Solubility | Insolubleinwater.Solubleinether,benzene,chloroformandacetone. |
| Appearance | WhiteSolid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | V0145InfoSheetPDF |
|---|
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GadSC,ReillyC,SiinoK,etal.Thirteencationicionophores:theiracutetoxicity,neurobehavioralandmembraneeffects.DrugChemToxicol.1985;8(6):451-68.PMID:4092618.
SeshachalamD,FrahmDH,FerraroFM.CationreversalofinhibitionofgrowthbyvalinomycininStreptococcuspyogenesandClostridiumsporogenes.AntimicrobAgentsChemother.1973Jan;3(1):63-7.PMID:4208280.
