Valinomycin is a peptide antibiotic originally produced by Streptomyces. Valinomycin displays antibacterial efficacy by inhibiting growth of Streptomyces and Clostridium. Valinomycin is a neutral ionophore that transports K+ ions through cellular membranes, altering the electrochemical gradient. In vitro, valinomycin induces mitochondrial damage, oxidative stress, and caspase expression.
| Cas No. | 2001-95-8 |
|---|---|
| Purity | ≥98% |
| Formula | C54H90N6O18 |
| Formula Wt. | 1111.32 |
| IUPAC Name | 6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone |
| Synonym | Valinomicin |
| Melting Point | 190°C |
| Solubility | Insoluble in water. Soluble in ether, benzene, chloroform and acetone. |
| Appearance | White Solid |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | V0145 Info Sheet PDF |
|---|
Li R, El-Mallahk RS. A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: caspase-3 dependency. Neurosci Lett. 2000 Nov 24;294(3):147-50. PMID: 11072136.
Gad SC, Reilly C, Siino K, et al. Thirteen cationic ionophores: their acute toxicity, neurobehavioral and membrane effects. Drug Chem Toxicol. 1985;8(6):451-68. PMID: 4092618.
Seshachalam D, Frahm DH, Ferraro FM. Cation reversal of inhibition of growth by valinomycin in Streptococcus pyogenes and Clostridium sporogenes. Antimicrob Agents Chemother. 1973 Jan;3(1):63-7. PMID: 4208280.
