Description
12-DesmethylSpirolideCisacycliciminemarinetoxininitiallyproducedbyspeciesofthedinoflagellateAlexandrium.SpirolideCisafast-actingshellfishpoisonthatinhibitsavarietyofnicotinicacetylcholinereceptors(nAChRs)suchasα7,α4β2,andα3β4.SpirolideCinhibitsnAChRsinskeletalmuscle,producingneuromuscularblock,andinneurons,decreasingactionpotentialduration.Thiscompoundalsoinhibitsmuscarinicacetylcholinereceptors(mAChRs).Additionally,spirolideCincreaseslevelsofN-acetylaspartateandsynaptophysinanddecreaseslevelsofamyloid-β(Aβ)inthehippocampusoftransgenicAlzheimer’sdiseasemousemodels.
References
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