15,16-Dehydrocafestolisaditerpenefoundinroastedcoffee.Thiscompoundisareductionproductofcafestol,whichinhibitsincreasesinpro-fibroticcytokineTGF-βinmodelsofliverdamageandinducesapoptosisthroughregulationofSp1signaling.15,16-Dehydrocafestolexhibitsanti-fibrotic,hepatoprotective,andanticanceractivities.Itmayalsoinduceapoptosisinmalignantpleuralmesotheliomacells.
| Purity | ≥98% |
|---|---|
| Formula | C20H26O2 |
| FormulaWt. | 298.42 |
| Synonym | Dehydrocafestol |
| MeltingPoint | 110-112°C |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D1731InfoSheetPDF |
|---|
ArauzJ,MorenoMG,Cortés-ReynosaP,etal.CoffeeattenuatesfibrosisbydecreasingtheexpressionofTGF-βandCTGFinamurinemodelofliverdamage.JApplToxicol.2013Sep;33(9):970-9.PMID:22899499.
LeeKA,ChaeJI,ShimJH.Naturalditerpenesfromcoffee,cafestolandkahweolinduceapoptosisthroughregulationofspecificityprotein1expressioninhumanmalignantpleuralmesothelioma.JBiomedSci.2012Jun26;19:60.PMID:22734486.
