15,16-Dehydrocafestol is a diterpene found in roasted coffee. This compound is a reduction product of cafestol, which inhibits increases in pro-fibrotic cytokine TGF-β in models of liver damage and induces apoptosis through regulation of Sp1 signaling. 15,16-Dehydrocafestol exhibits anti-fibrotic, hepatoprotective, and anticancer activities. It may also induce apoptosis in malignant pleural mesothelioma cells.
| Purity | ≥98% |
|---|---|
| Formula | C20H26O2 |
| Formula Wt. | 298.42 |
| Synonym | Dehydrocafestol |
| Melting Point | 110-112°C |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | D1731 Info Sheet PDF |
|---|
Arauz J, Moreno MG, Cortés-Reynosa P, et al. Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage. J Appl Toxicol. 2013 Sep;33(9):970-9. PMID: 22899499.
Lee KA, Chae JI, Shim JH. Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma. J Biomed Sci. 2012 Jun 26;19:60. PMID: 22734486.
