LKT/TRIPTOLIDE/T7035/1 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/TRIPTOLIDE/T7035/1 mg

LKT/TRIPTOLIDE/T7035/1 mg

商品编号： T7035-1mg

品牌： lktlabs

市场价： ¥660.00

美元价： 396.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDT7035

CasNo.38748-32-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

TriptolideisaditerpenoidepoxideoriginallyfoundinTripterygiumthatexhibitsanticancerchemotherapeutic,anti-angiogenic,antinociceptive,anti-inflammatory,anti-fibrotic,andimmunosuppressiveactivities.Triptolideinducesapoptosisanddecreasesβ-cateninexpressioninbreastcancercells.Incellularandanimalmodelsofpancreaticcancer,triptolideinhibitscellproliferationandxenograftgrowth,downregulatesexpressionofCOX-2andVEGF,andsuppressescellmigrationandtubeformation.Inanimalmodels,chronicadmiNISTrationoftriptolidedecreasesactivationofglialcellsandphosphorylationofMAPKs,suppressingneuropathicpain.Additionally,triptolidedecreasesexpressionofIL-17andSTAT3andsuppressesneutrophilmigration,displayinghepatoprotectivebenefitinanimalmodelsofliverischemia/reperfusioninjury.Triptolidealsopreventsthedevelopmentofcardiacfibrosisandimprovescardiacfunctioninanimalmodelsofchronicheartfailure.

ProductInfo

CasNo.	38748-32-2
Purity	≥98%
Formula	C₂₀H₂₄O₆
FormulaWt.	360.40
Synonym	PG490
MeltingPoint	227-228°C
Solubility	SolubleinDMSO.
Appearance	WhitePowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

InfoSheet	T7035InfoSheetPDF
Brochures	WNTBooklet

References

LiuM,ChenJ,HuangY,etal.Triptolidealleviatesisoprenaline-inducedcardiacremodelinginratsviaTGF-β1/Smad3andp38MAPKsignalingpathway.Pharmazie.2015Apr;70(4):244-50.PMID:26012254.

ShaoH,MaJ,GuoT,etal.TriptolideinducesapoptosisofbreastcancercellsviaamechanismassociatedwiththeWnt/β-cateninsignalingpathway.ExpTherMed.2014Aug;8(2):505-508.PMID:25009609.

MaJX,SunYL,WangYQ,etal.TriptolideinducesapoptosisandinhibitsthegrowthandangiogenesisofhumanpancreaticcancercellsbydownregulatingCOX-2andVEGF.OncolRes.2013;20(8):359-68.PMID:23924856.

WangW,MeiXP,ChenL,etal.Triptolidepreventsandattenuatesneuropathicpainviainhibitingcentralimmuneresponse.PainPhysician.2012Nov-Dec;15(6):E995-1006.PMID:23159984.

WuC,XiaY,WangP,etal.Triptolideprotectsmicefromischemia/reperfusioninjurybyinhibitionofIL-17production.IntImmunopharmacol.2011Oct;11(10):1564-72.PMID:21621648.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂