α-Conotoxin GI is a peptide inhibitor of nicotinic acetylcholine receptors (nAChRs) originally found in species of Conus snails. α-Conotoxin GI binds nAChRs at αγ and αδ interfaces. α-Conotoxin GI decreases peak amplitude and induces tetanic and train-of-four fades, modulating acetylcholine signaling at the neuromuscular junction.
| Purity | ≥95% |
|---|---|
| Formula | C55H76N20O18S4 |
| Formula Wt. | 1433.63 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C5655 Info Sheet PDF |
|---|
Hann RM, Pagán OR, Gregory LM, et al. The 9-arginine residue of alpha-conotoxin GI is responsible for its selective high affinity for the alphagamma agonist site on the electric organ acetylcholine receptor. Biochemistry. 1997 Jul 22;36(29):9051-6. PMID: 9220994.
Blount K, Johnson A, Prior C, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42. PMID: 1355934.
