AK-1isaninhibitorofsirtuin2(SIRT2);sirtuinsareconsideredclassIIIhistonedeacetylases(HDACs).AK-1exhibitsneuroprotectiveandanticanceractivities.ThiscompoundpreventssomehippocampalneurodegenerationinanimalmodelsofAlzheimer’sdisease.AK-1alsoinducescellcyclearrestincoloncarcinomacellsbydownregulatingexpressionofSnail.
| CasNo. | 330461-64-8 |
|---|---|
| Purity | ≥99% |
| Formula | C19H21N3O5S |
| FormulaWt. | 403.45 |
| IUPACName | 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide |
| Synonym | SIRT2inhibitorII |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A4000InfoSheetPDF |
|---|
CheonMG,KimW,ChoiM,etal.AK-1,aspecificSIRT2inhibitor,inducescellcyclearrestbydownregulatingSnailinHCT116humancoloncarcinomacells.CancerLett.2015Jan28;356(2PtB):637-45.PMID:25312940.
Spires-JonesTL,FoxLM,RozkalneA,etal.InhibitionofSirtuin2withSulfobenzoicAcidDerivativeAK1isNon-ToxicandPotentiallyNeuroprotectiveinaMouseModelofFrontotemporalDementia.FrontPharmacol.2012Mar12;3:42.PMID:22416232.
