Description
AK-7isaninhibitorofsirtuin2(SIRT2);sirtuinsareconsideredclassIIIhistonedeacetylases(HDACs).AK-7exhibitsneuroprotectiveactivity,decreasingbrainatrophyandimprovingmotorfunctionandsurvivalinanimalmodelsofHuntington’sdisease.
AK-7isaninhibitorofsirtuin2(SIRT2);sirtuinsareconsideredclassIIIhistonedeacetylases(HDACs).AK-7exhibitsneuroprotectiveactivity,decreasingbrainatrophyandimprovingmotorfunctionandsurvivalinanimalmodelsofHuntington’sdisease.
CasNo. | 420831-40-9 |
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Purity | ≥98% |
Formula | C19H21BrN2O3S |
FormulaWt. | 437.35 |
IUPACName | 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide |
Synonym | AK7 |
Appearance | Whitetooffwhitepowder |
StoreTemp | -20°C |
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ShipTemp | Ambient |
InfoSheet | A4002InfoSheetPDF |
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ChopraV,QuintiL,KimJ,etal.Thesirtuin2inhibitorAK-7isneuroprotectiveinHuntington"sdiseasemousemodels.CellRep.2012Dec27;2(6):1492-7.PMID:23200855.