LKT/AMITRIPTYLINE HYDROCHLORIDE/A5235/10 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/AMITRIPTYLINE HYDROCHLORIDE/A5235/10 g

LKT/AMITRIPTYLINE HYDROCHLORIDE/A5235/10 g

商品编号： A5235-10g

品牌： lktlabs

市场价： ¥920.00

美元价： 552.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDA5235

CasNo.549-18-8

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Amitriptylineexhibitsantidepressant,antipsychotic,analgesic,andantinociceptiveactivities;itactsasanantagoNISTat5-HT2A/2C/6/7receptors,M1-5muscarinicacetylcholinereceptors(mAChRs),H1/4histaminereceptors,α1-adrenergicreceptors,andalsoontheSEROtonintransporter(SERT)andnorepinephrinetransporter(NET).Additionally,amitriptylineactsasanagonistatσ1receptorsandTrkA/Breceptors.Amitriptylineinhibitsshaker-relatedKv1.1(KCNA1),Kv7.2(KCNQ2),andKv7.3(KCNQ3)voltage-gatedK+channelsandL-typevoltage-gatedCa2+channels;itinhibitsexpressionofNav1.1(SCN1A)andNav1.2(SCN2A)voltage-gatedNa+channelsandactivatesryanodineRyR2receptors.Amitriptylinealsodecreaseslevelsofα1-adrenergicreceptorsinthecortexandcerebelluminvivo.Inanimalmodelsofchronicconstrictiveinjuryandneuropathicpain,amitriptylinedecreasesthermalhyperanalgesia.InPC12neurons,thiscompoundexhibitsneuroprotectiveactivity,increasingneuriteoutgrowthanddecreasingcelldeath.Amitriptyleneisalsoafunctioninhibitorofacidsphingomyelinase(FIASMA).

ProductInfo

CasNo.	549-18-8
Purity	≥98%
Formula	C₂₀H₂₃N•HCl
FormulaWt.	313.86
IUPACName	3-(5,6-dihydrodibenzo[2,1-b:2",1"-f][7]annulen-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
Synonym	3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethyl-1-propanaminehydrochloride
MeltingPoint	195-197C
Solubility	Solubleinwater,ethanol,DMSO
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	A5235InfoSheetPDF

References

Effectsofchronicadministrationofamitriptyline,gabapentinandminocyclineonspinalbrain-derivedneurotrophicfactorexpressionandneuropathicpainbehaviorinaratchronicconstrictioninjurymodel.
VanelderenP,RouwetteT,KoziczT,HeylenR,VanZundertJ,RoubosEW,VissersK.
RegAnesthPainMed.2013Mar-Apr;38(2):124-30.PMID:23337936.

RamakrishnaD,SubhashMN.Differentialmodulationofα-1adrenoceptorsubtypesbyantidepressantsintheratbrain.JNeuralTransm.2010Dec;117(12):1423-30.PMID:21136124.

YanL,WangQ,FuQ,etal.AmitriptylineinhibitscurrentsanddecreasesthemRNAexpressionofvoltage-gatedsodiumchannelsinculturedratcorticalneurons.BrainRes.2010Jun8;1336:1-9.PMID:20398637.

JangSW,LiuX,ChanCB,etal.AmitriptylineisaTrkAandTrkBreceptoragonistthatpromotesTrkA/TrkBheterodimerizationandhaspotentneurotrophicactivity.ChemBiol.2009Jun26;16(6):644-56.PMID:19549602.

ChopraN,LaverD,DaviesSS,etal.Amitriptylineactivatescardiacryanodinechannelsandcausesspontaneoussarcoplasmicreticulumcalciumrelease.MolPharmacol.2009Jan;75(1):183-95.PMID:18845675.

WerlingLL,KellerA,FrankJG,etal.Acomparisonofthebindingprofilesofdextromethorphan,memantine,fluoxetineandamitriptyline:treatmentofinvoluntaryemotionalexpressiondisorder.ExpNeurol.2007Oct;207(2):248-57.PMID:17689532.

PunkeMA,FriederichP.AmitriptylineisapotentblockerofhumanKv1.1andKv7.2/7.3channels.AnesthAnalg.2007May;104(5):1256-64.PMID:17456683.

OwensMJ,MorganWN,PlottSJ,etal.Neurotransmitterreceptorandtransporterbindingprofileofantidepressantsandtheirmetabolites.JPharmacolExpTher.1997Dec;283(3):1305-22.PMID:9400006.

HamonM,GozlanH,BourgoinS,etal.OpioidreceptorsandneuropeptidesintheCNSinratstreatedchronicallywithamoxapineoramitriptyline.Neuropharmacology.1987Jun;26(6):531-9.PMID:3037421.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂