Amygdalinisaglucosidefoundinstonefruitsandapplesthatexhibitsantinociceptive,analgesic,andanticancerchemotherapeuticactivities.Inanimalmodels,amygdalindecreasesformalin-inducedpain.AmygdalininhibitsviABIlityofleukemiacellsandinducesapoptosisinprostatecancercells,increasinglevelsofBaxanddecreasinglevelsofBcl-2;invivo,amygdalininducesapoptosisandinhibitstumorxenograftgrowth.
| CasNo. | 29883-15-6 |
|---|---|
| Purity | ≥98% |
| Formula | C20H27NO11 |
| FormulaWt. | 457.43 |
| ChemicalName | [(6-O-β-D-glucopyranosyl-beta-D-gluco-pyranosyl-β-D-gluco-pyranosyl)oxy]-benzeneacetonitrile |
| IUPACName | 2-phenyl-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyacetonitrile |
| Synonym | Amygdaloside |
| MeltingPoint | 210ªC-215°C |
| Solubility | Solubleinhotwater(0.1g/mL)oralcohol(1g/900mL). |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A5193MSDSPDF |
|---|---|
| InfoSheet | A5193InfoSheetPDF |
ChenY,MaJ,WangF,etal.AmygdalininducesapoptosisinhumancervicalcancercelllineHeLacells.ImmunopharmacolImmunotoxicol.2013Feb;35(1):43-51.PMID:23137229.
HwangHJ,KimP,KimCJ,etal.AntinociceptiveeffectofamygdalinisolatedfromPrunusarmeniacaonformalin-inducedpaininrats.BiolPharmBull.2008Aug;31(8):1559-64.PMID:18670089.
ChangHK,ShinMS,YangHY,etal.AmygdalininducesapoptosisthroughregulationofBaxandBcl-2expressionsinhumanDU145andLNCaPprostatecancercells.BiolPharmBull.2006Aug;29(8):1597-602.PMID:16880611.
