Amyloid-β(Aβ)isapeptidecleavageproductofamyloidprecursorprotein(APP)thatisoftenusedasabioMarkerinAlzheimer’sdisease.MisfoldedAβoligomersinstigateconformationchangesinother,normallyfoldedAβoligomers,increasingthenumberofmisfoldedproteinsandeventuallyformingneurotoxicplaques.Theseplaquesimpaircognitiveperformanceinvivo.
| CasNo. | 131602-53-4 |
|---|---|
| Purity | ≥95% |
| Formula | C45H81N13O14S |
| FormulaWt. | 1060.27 |
| IUPACName | 2-[[2-[[2-[[2-[[2-[2-[[2-[[6-amino-2-[[4-amino-2-[[2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]propanoylamino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoicacid |
| Synonym | Amyloid-betaproteinfragment(25-35) |
| Solubility | Solubleinwater(~6mg/mL).Notdirectlysolubleinbufferorsaline. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A4849InfoSheetPDF |
|---|
HuJ,el-FakahanyEE.Neuroreport.4(6):760-762(1993).JiaJ,KangL,LiS,etal.AmelioratoryeffectsoftestosteronetreatmentoncognitiveperformancedeficitsinducedbysolubleAβ1-42oligomersinjectedintothehippocampus.HormBehav.2013Aug;64(3):477-86.PMID:23954394.
YinYI,BassitB,ZhuL,etal.gamma-SecretaseSubstrateConcentrationModulatestheAbeta42/Abeta40Ratio:ImplicationsforAlzheimerDisease.JBiolChem.2007Aug10;282(32):23639-44.PMID:17556361.
HartmannT,BiegerSC,BrühlB,etal.DistinctsitesofintracellularproductionforAlzheimer"sdiseaseAbeta40/42amyloidpeptides.NatMed.1997Sep;3(9):1016-20.PMID:9288729.
