Description
AnisomycinisanantibioticinitiallyproducedbyStreptomycesthatretainsnoantibacterialactivity.Anisomycinexhibitsneuromodulatoryandanticancerchemotherapeuticactivities.Anisomycininhibitspeptidyltransferaseinthe80Sribosome,suppressingproteinsynthesis.Inanimalmodels,anisomycindecreasesfacilitationoffearconditioningpre-shock;italsoinhibitsconsolidationandreconsolidationinincentivelearningmodels.Anisomycininducesapoptosisandinhibitscellproliferationinbreastcancercells.AnisomycinalsoinhibitsgrowthofEhrlichascitescarcinomacellsinvitroandinvivo,inducingcaspase-dependentapoptosisandDNAstrandbreakage.Additionally,thiscompoundinhibitsexpressionofCDK2andactivatesp53,p21,andp27,inducingcellcyclearrestandinhibitingcellproliferationinJurkatTcells.
References
MonaghanD,O"ConnellE,CruickshankFL,etal.InhibitionofproteinsynthesisandJNKactivationarenotrequiredforcelldeathinducedbyanisomycinandanisomycinanalogues.BiochemBiophysResCommun.2014Jan10;443(2):761-7.PMID:24333448.
YuC,XingF,TangZ,etal.AnisomycinsuppressesJurkatTcellgrowthbythecellcycle-regulatingproteins.PharmacolRep.2013;65(2):435-44.PMID:23744428.
YouP,XingF,HuoJ,etal.InvitroandinvivoevaluationofanisomycinagainstEhrlichascitescarcinoma.OncolRep.2013Jun;29(6):2227-36.PMID:23525555.
WangSH,OstlundSB,NaderK,etal.Consolidationandreconsolidationofincentivelearningintheamygdala.JNeurosci.2005Jan26;25(4):830-5.PMID:15673662.
BarrientosRM,O"ReillyRC,RudyJW.Memoryforcontextisimpairedbyinjectinganisomycinintodorsalhippocampusfollowingcontextexploration.BehavBrainRes.2002Aug21;134(1-2):299-306.PMID:12191817.
GrollmanAP.Inhibitorsofproteinbiosynthesis.II.Modeofactionofanisomycin.JBiolChem.1967Jul10;242(13):3226-33.PMID:6027796.
