Description
ZonampanelisaneuroprotectiveAMPAreceptorantagoNISTthatiscurrentlyunderexaminationasapotentialtreatmentforcerebralischemia/stroke.Inanimalmodelsofstroke,zonampanelimprovesneurologicaldeficitsbutdoesnotexacerbateintracerebralhemorrhage.
ZonampanelisaneuroprotectiveAMPAreceptorantagoNISTthatiscurrentlyunderexaminationasapotentialtreatmentforcerebralischemia/stroke.Inanimalmodelsofstroke,zonampanelimprovesneurologicaldeficitsbutdoesnotexacerbateintracerebralhemorrhage.
CasNo. | 210245-80-0 |
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Purity | ≥97% |
Formula | C13H9N5O6 |
FormulaWt. | 331.24 |
ChemicalName | (2,3-Dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)aceticacidmonohydrate |
IUPACName | 2-(7-imidazol-1-yl-6-nitro-2,3-dioxo-4H-quinoxalin-1-yl)aceticacid |
Synonym | YM872,HY-15072 |
Solubility | SolubilityinbufferpH7is≥80mg/mL. |
Appearance | YelowishtoTanPowder |
StoreTemp | Ambient |
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ShipTemp | Ambient |
InfoSheet | Z5852InfoSheetPDF |
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FerroJM,DávalosA.Otherneuroprotectivetherapiesontrialinacutestroke.CerebrovascDis.2006;21Suppl2:127-30.PMID:16651823.
TeraiK,SuzukiM,SasamataM,etal.EffectofAMPAreceptorantagonistYM872oncerebralhematomasizeandneurologicalrecoveryintheintracerebralhemorrhageratmodel.EurJPharmacol.2003Apr25;467(1-3):95-101.PMID:12706461.