Angiotensin III (AT III) is the smallest, least active peptide fragment of precursor angiotensinogen. AT III is an endogenous peptide produced by the degradation of AT II by angiotensinase. AT III has 40% of the vasoconstrictive pressor activity of AT II but increases aldosterone secretion and mean arterial pressure through activity at the AT II type 1 (AT1) receptor.
| Cas No. | 12687-51-3 |
|---|---|
| Purity | ≥98% |
| Formula | C46H66N12O9 |
| Formula Wt. | 931.10 |
| Solubility | Soluble in 5% acetic acid or in water (1 mg/mL). |
| Appearance | White to Off-white Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | A5278 Info Sheet PDF |
|---|
Yugandhar VG, Clark MA. Angiotensin III: a physiological relevant peptide of the renin angiotensin system. Peptides. 2013 Aug;46:26-32. PMID: 23692861.
Yang R, Smolders I, Dupont AG. Blood pressure and renal hemodynamic effects of angiotensin fragments. Hypertens Res. 2011 Jun;34(6):674-83. PMID: 21412242.
Dupont AG, Brouwers S. Brain angiotensin peptides regulate sympathetic tone and blood pressure. J Hypertens. 2010 Aug;28(8):1599-610. PMID: 20502352.
