Thymic factor (thymulin) is an endogenous peptide that modulates immune and neuroendocrine signaling pathways. Thymic factor induces immunoneutralization and decreases secretion of prolactin and growth hormone (GH). In animal models of experimental autoimmune encephalitis (EAE), thymic factor prevents activation of p38 MAPK and NF-κB and release of pro-inflammatory cytokines, decreasing overall disease severity.
| Purity | ≥95% |
|---|---|
| Formula | C33H57N13O15 |
| Formula Wt. | 875.9 |
| Synonym | Thymulin, Thymic factor, FTS |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | T3099 Info Sheet PDF |
|---|
Martines EV, Reggiani PC, Camihort G, et al. The thymulin-lactotropic axis in rodents: thymectomy, immunoneutralization and gene transfer studies. Neuroimmunomodulation. 2013;20(5):256-63. PMID: 23941809.
Lunin SM, Glushkova OV, Khrenov MO, et al. Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis. Immunobiology. 2013 Mar;218(3):402-7. PMID: 22727332.
Reggiani PC, Martines EV, Camihort GA, et al. Role of thymulin on the somatotropic axis in vivo. Life Sci. 2012 Sep 4;91(5-6):166-71. PMID: 22781709.
Santos M, Henriques-Coelho T, Leite-Moreira A. Immunomodulatory role of thymulin in lung diseases. Expert Opin Ther Targets. 2010 Feb;14(2):131-41. PMID: 20055713.
Goya RG, Bolognani F. Homeostasis, thymic hormones and aging. Gerontology. 1999 May-Jun;45(3):174-8. PMID: 10202264.
