Description
Thyrotropin-releasing hormone (TRH) is an endogenous tripeptide amide that acts as a neurotransmitter and neurohormone. TRH regulates hypothalamic-pituitary-adrenal (HPA) and estrogenic signaling pathways. TRH exhibits immunomodulatory and neuroprotective activities. TRH prevents oxidative stress, caspase-mediated apoptosis, glutamate toxicity, and neuroinflammation. Additionally, TRH stimulates epidermal regeneration in ex vivo models, activating would healing. TRH activates the TRH receptor.
References
Fekete C, Lechan RM. Central Regulation of Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions. Endocr Rev. 2013 Dec 4:er20131087. [Epub ahead of print]. PMID: 24423980.
Pekary AE, Sattin A. Increased TRH and TRH-like peptide release in rat brain and peripheral tissues during proestrus/estrus. Peptides. 2013 Dec 1;52C:1-10. PMID: 24296042.
Daimon CM, Chirdon P, Maudsley S, et al. The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases. Am J Alzheimers Dis (Columbia). 2013;1(1). PMID: 24199031.
Meier NT, Haslam IS, Pattwell DM, et al. Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin. PLoS One. 2013 Sep 2;8(9):e73596. PMID: 24023889.
