Triptorelinisapeptideanalogofgonadotropin-releasinghormone(GnRH)thatinducesconstantstimulationofthepituitarygland,decreasingreleaseofluteinizinghormone(LH)andfollicle-stimulatinghormone(FSH).Triptorelinexhibitsanticancerandanxiolyticactivities.Triptorelininhibitscellproliferationincellularmodelsofbreastcancerandovariancancer.Thiscompoundalsoincreasesopenarmentriesandsocialinteractiontimeinanimalmodelsofanxiety.
| CasNo. | 57773-63-4 |
|---|---|
| Purity | ≥98% |
| Formula | C64H83N18O13 |
| FormulaWt. | 1311.5 |
| ChemicalName | 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide |
| IUPACName | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| Synonym | Decapeptyl;[DTrp6]-LH-RH,Amide |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T7036InfoSheetPDF |
|---|
Saleh-AbadyMM,AlizadehA,ShamsipourF,etal.Theanticanceractivitycomparedbetweentriptorelinandanewgonadotropinreleasinghormoneanalogue.AvicennaJMedBiotechnol.2009Jul;1(2):105-10.PMID:23407883.
UmatheSN,BhutadaPS,JainNS,etal.EffectsofcentraladmiNISTrationofgonadotropin-releasinghormoneagonistsandantagonistonelevatedplus-mazeandsocialinteractionbehaviorinrats.BehavPharmacol.2008Jul;19(4):308-16.PMID:18622178.
