Triptorelin is an analog of gonadotropin-releasing hormone I (GnRH-I); it is a decapeptide that activates the GnRH receptor in the pituitary gland, decreasing secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Triptorelin inhibits production of cAMP in a Ca2+- and PKC-dependent manner. Triptorelin exhibits anxiolytic and potentially anticancer activities. In vitro, triptorelin’s modulation of autocrine regulatory signaling may induce cell cycle arrest.
| Cas No. | 140194-24-7 |
|---|---|
| Purity | ≥95% |
| Formula | C64H82N18O13 • C2H4O2 |
| Formula Wt. | 1371.52 |
| IUPAC Name | acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| Appearance | White Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | T7037 Info Sheet PDF |
|---|
Saleh-Abady MM, Alizadeh A, Shamsipour F, et al. The anticancer activity compared between triptorelin and a new gonadotropin releasing hormone analogue. Avicenna J Med Biotechnol. 2009 Jul;1(2):105-10. PMID: 23407883.
Larivière S, Garrel-Lazayres G, Simon V, et al. Gonadotropin-releasing hormone inhibits pituitary adenylyl cyclase-activating polypeptide coupling to 3',5'-cyclic adenosine-5'-monophosphate pathway in LbetaT2 gonadotrope cells through novel protein kinase C isoforms and phosphorylation of pituitary adenylyl cyclase-activating polypeptide type I receptor. Endocrinology. 2008 Dec;149(12):6389-98. PMID: 18755795.
Umathe SN, Bhutada PS, Jain NS, et al. Effects of central administration of gonadotropin-releasing hormone agonists and antagonist on elevated plus-maze and social interaction behavior in rats. Behav Pharmacol. 2008 Jul;19(4):308-16. PMID: 18622178.
Kim JW, Lee YS, Kim BK, et al. Cell cycle arrest in endometrial carcinoma cells exposed to gonadotropin-releasing hormone analog. Gynecol Oncol. 1999 Jun;73(3):368-71. PMID: 10366462.
