Triptorelinisananalogofgonadotropin-releasinghormoneI(GnRH-I);itisadecapeptidethatactivatestheGnRHreceptorinthepituitarygland,decreasingsecretionofluteinizinghormone(LH)andfollicle-stimulatinghormone(FSH).TriptorelininhibitsproductionofcAMPinaCa2+-andPKC-dependentmanner.Triptorelinexhibitsanxiolyticandpotentiallyanticanceractivities.Invitro,triptorelin’smodulationofautocrineregulatorysignalingmayinducecellcyclearrest.
| CasNo. | 140194-24-7 |
|---|---|
| Purity | ≥95% |
| Formula | C64H82N18O13•C2H4O2 |
| FormulaWt. | 1371.52 |
| IUPACName | aceticacid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| Appearance | WhitePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | T7037InfoSheetPDF |
|---|
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KimJW,LeeYS,KimBK,etal.Cellcyclearrestinendometrialcarcinomacellsexposedtogonadotropin-releasinghormoneanalog.GynecolOncol.1999Jun;73(3):368-71.PMID:10366462.
