Uroguanylin is an endogenous natriuretic peptide that modulates activity through Na+/H+ exchangers in intestinal and renal tissues, altering electrolyte and water transport. Uroguanylin activates guanylyl cyclase receptors to increase cGMP production. Uroguanylin also increases activity of Cl- channels. Uroguanylin inhibits bicarbonate reabsorption and increases net water secretion through signaling cascades mediated by PKA and PKG.
| Purity | ≥95% |
|---|---|
| Formula | C64H102N18O26S4 |
| Formula Wt. | 1667.89 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | U6956 Info Sheet PDF |
|---|
Teixeira MD, Nascimento NR, Fonteles MC, et al. Uroguanylin induces electroencephalographic spikes in rats. Braz J Biol. 2013 Aug;73(3):623-7. PMID: 24212704.
Lessa LM, Carraro-Lacroix LR, Crajoinas RO, et al. Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule. Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1399-408. PMID: 22952280.
Toriano R, Ozu M, Politi MT, et al. Uroguanylin regulates net fluid secretion via the NHE2 isoform of the Na/H+ exchanger in an intestinal cellular model. Cell Physiol Biochem. 2011;28(4):733-42. PMID: 22178885.
