UroguanylinisanendogenousnatriureticpeptidethatmodulatesactivitythroughNa+/H+exchangersinintestinalandrenaltissues,alteringelectrolyteandwatertransport.UroguanylinactivatesguanylylcyclasereceptorstoincreasecGMPproduction.UroguanylinalsoincreasesactivityofCl-channels.UroguanylininhibitsbicarbonatereabsorptionandincreasesnetwatersecretionthroughsignalingcascadesmediatedbyPKAandPKG.
| Purity | ≥95% |
|---|---|
| Formula | C64H102N18O26S4 |
| FormulaWt. | 1667.89 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | U6956InfoSheetPDF |
|---|
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TorianoR,OzuM,PolitiMT,etal.UroguanylinregulatesnetfluidsecretionviatheNHE2isoformoftheNa/H+exchangerinanintestinalcellularmodel.CellPhysiolBiochem.2011;28(4):733-42.PMID:22178885.
