Description
Transientreceptorpotentialvanilloid1(TRPV1)channelsareactivatedbyheat,proton,endovanilloids,endocannABInoids,andinflammatorymediators.TRPV1isalsoconsideredthecapsaicinreceptor;itmodulatesneurotransmissionandpain/nociceptivesignaling.TRPV1isexpressedonneuronsinarteries,bloodvessels,skintissues,andinthebrain.ActivationofTRPV1mayresultinskeletalmuscleconstrictionandarterialvasoconstriction.
References
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TóthA,CzikoraA,PásztorET,etal.VanilloidReceptor-1(TRPV1)ExpressionandFunctionintheVasculatureoftheRat.JHistochemCytochem.2013Dec5.[Epubaheadofprint].PMID:24217926.
KellyS,ChapmanRJ,WoodhamsS,etal.IncreasedfunctionofpronociceptiveTRPV1atthelevelofthejointinaratmodelofosteoarthritispain.AnnRheumDis.2013Oct23.[Epubaheadofprint].PMID:24152419.