AZD-8931isaninhibitorofEGFR,HER2,andHER3thatexhibitsanticancerchemotherapeuticactivity.Invitroandinvivo,AZD-8931suppressesgrowthofinflammatorybreastcancercellsandtumorsandinducesapoptosis.Thiscompoundalsoinhibitsgrowthincellularmodelsofnon-smallcelllungcancer(NSCLC)andsquamouscellcarcinoma.
| CasNo. | 848942-61-0 |
|---|---|
| Purity | ≥98% |
| Formula | C23H25ClFN5O3 |
| FormulaWt. | 473.93 |
| IUPACName | 2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide |
| Synonym | AZD8931,Sapitinib |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A9813InfoSheetPDF |
|---|
MuZ,KlinowskaT,DongX,etal.AZD8931,anequipotent,reversIBLeinhibitorofsignalingbyepidermalgrowthfactorreceptor(EGFR),HER2,andHER3:preclinicalactivityinHER2non-amplifiedinflammatorybreastcancermodels.JExpClinCancerRes.2014May30;33:47.PMID:24886365.
TjulandinS,MoiseyenkoV,SemiglazovV,etal.PhaseI,dose-findingstudyofAZD8931,aninhibitorofEGFR(erbB1),HER2(erbB2)andHER3(erbB3)signaling,inpatientswithadvancedsolidtumors.InvestNewDrugs.2014Feb;32(1):145-53.PMID:23589215.
HickinsonDM,KlinowskaT,SpeakeG,etal.AZD8931,anequipotent,reversibleinhibitorofsignalingbyepidermalgrowthfactorreceptor,ERBB2(HER2),andERBB3:auniqueagentforsimultaneousERBBreceptorblockadeincancer.ClinCancerRes.2010Feb15;16(4):1159-69.PMID:20145185.
