BleomycinA5isananticancerchemotherapeuticthatbindsDNAandinducesDNAcleavageandstrandbreaks;itishighlytoxic.Bleomycinisclinicallyusedtotreatlymphomas,squamouscellcarcinomas,andtesticularcancer.Additionally,thiscompoundinducesapoptosis,alterscellcycleregulation,inhibitsproliferation,anddecreasestumorsizeincellularandanimalmodelsofhemangioma.Bleomycinmayalsoinhibitthioredoxinreductase.
| Purity | ≥85% |
|---|
| InfoSheet | B4514InfoSheetPDF |
|---|
LiP,LiDF,GuoZT,etal.TherapeuticmechanismofbleomycinA5oninfancyhemangioma:anexperimentalstudy.ZhonghuaKouQiangYiXueZaZhi.2013Jan;48(1):18-22.PMID:23534516.
YangY,SunM,MaQ,etal.BleomycinA5sclerotherapyforcervicofaciallymphaticmalformations.JVascSurg.2011Jan;53(1):150-5.PMID:20843632.
LiuY,WuF,ZouG.ElectrophoresismobilityshiftassayandbiosensorusedinstudyingtheinteractionbetweenbleomycinA5andDNA.AnalChimActa.2007Sep19;599(2):310-4.PMID:17870295.
VorobjevPE,SmithJB,PyshnayaIA,etal.Site-specificcleavageofRNAandDNAbycomplementaryDNA--bleomycinA5conjugates.BioconjugChem.2003Nov-Dec;14(6):1307-13.PMID:14624648.
